大鼠子代低出生体重追赶式肥胖与成年后高血压和糖尿病的相关性研究

Objective: To study the relationship between the offspring of low birth weight, catch-up growth and hypertension and diabetes during adulthood in the rats. Methods: The rats were divided into normal control group (Ctrl group) and light restraint group ( Lg group). The rats in the Lg group were exposed in light and restricted during the late pregnancy. After they gave birth, all of the birth weights of offspring were recorded. Then we raised the offspring until 4 months old, some individuals were detected in blood pressure and glucose tolerance test and insulin resistance test. Results: Both the male and female Lg group of new born offspring showed significantly lower weight than Ctrll group. Children adult blood pressure of the Lg group was obviously higher than that of control group. Offspring of Lg group showed abnormal glucose tolerance and insulin resistance. Conclusion: Late pregnancy stress stimuli can cause low birth weight of the offspring. Low birth weight offspring may show catch-up growth which leads to adipose accumulation in abdominal, and it is easier to suffer from high blood pressure and diabetes during adulthood.