青鲜素对大鼠肝脏氧化-抗氧化系统平衡的影响

objective: To study the effects of Maleic Hydrozine on oxidative stress in liver of rat, to explore its mechanisms of toxicity to the rat in the perspective of oxidative damage. Methods: 40 healthy SD rats were randomly divided into four groups: blank control group, low-dose group, moderate-dose group, high-dose group. The rats were exposed to MH through mouth, once a day for two consecutive weeks. The four groups were treated with dosages of 125mg/kg, 250mg/kg, 500mg/kg. 24 hours after the 2 weeks treatment, measure the weight and wet weight of the organs, calculate the ratio of the organs. Measure the content of malondialdehyde(MDA), the activity of superoxide dismutase(SOD), glutathione peroxidase(GSH-Px) in liver. Results: The activity of SOD and GSH-Px was significantly lower than those in the control group(P<0.05).The activity of SOD decreased by 78.7% at 500mg/kg dose levels; the activity of GSH-Px decreased by 47.4%、48.3% at 250mg/kg,500mg/kg dose levels; the content of MDA increased, but not significantly(P>0.05).Conclusion: MH exposure damages the rat's liver, the mechanisms of toxicity may be that MH exposure breaks the balance of the oxidant-antioxidant system and effects the activity of the SOD and GSH-Px in the liver.