Magnetocontrolled protein membranes for cell cultures co-cultivation

Abstract Investigation of cells and tissues in vitro systems is an attempt to simplify the very complex interactions between the various cell types from multicellular organisms. Monolayer cell cultures with single cell type do not allow to show all the possible paracrine interactions between various types of cells. To analyze intercellular inter-actions, it is possible to use systems that co-cultivate several cell types. This article proposes a new cell co-cultivation system based on levitation in the magnetic field in the culture medium of a magnetic protein membrane with cells. The developed system of co-cultivation of cells can be made in any laboratory of available reagents and have a low manufacturing cost.