肾癌中netrin-1的表达及意义
Significance of netrin-1 expression in kidney carcinoma
目的：研究轴突导向因子netrin-1在肾癌组织和肾癌细胞系中的表达，以发现肾癌发生发展的新通路，为肾癌的治疗提供新的思路。方法：采用实时定量PCR技术和western blotting技术检测netrin-1的表达。结果：肾癌组织中netrin-1的表达要明显高于癌旁正常组织，在高侵袭生长的肾癌细胞系ACHN中，netrin-1的表达要高于低侵袭生长的细胞系769-P，mRNA和蛋白表达呈现相同趋势。结论：netrin-1可能和肾癌的发生发展密切相关，可为肾癌治疗提供新靶点。
Objectives: To study the expression and significance of nerin-1 in kidney carcinoma tissues and cell lines. Methods: RT-PCR and western blotting analysis were used to detect the expression of netrin-1.Results: The expression of netrin-1 in tumor tissues was significantly upregulated compared to the corresponding normal tissues. Netrin-1 was upregulated in highly metastatic epithelial cell lines. Conclusions: Netrin-1 genes might participate in the development and progression of kidney cell carcinoma.
张哲、詹博、孔垂泽
肿瘤学基础医学生物科学研究方法、生物科学研究技术
外科学肾癌netrin-1
Surgerykidney carcinomanetrin-1
张哲,詹博,孔垂泽.肾癌中netrin-1的表达及意义[EB/OL].(2013-02-13)[2025-05-17].http://www.paper.edu.cn/releasepaper/content/201302-246.点此复制
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