利用微通道制备超分子水凝胶载药微球及其释药性能的研究

In this paper，a hydrogel GL-PhD was synthesized by BOC-L-phenylalanine. The supramolecular hydrogel drug-carrier microspheres was formed by the self-assembly of the gelator in the microchannel (ciprofloxacin hydrochloride used as model drug). The drug release properties were studied in different conditions. The effects of the particle size of supramolecular hydrogel microspheres, the gelator concentration, pH and the temperature on drug release were studied. And the results showed that the drug in the supramolecular hydrogel microspheres could be released to the external environment though the diffusion effect. In addition, the release rate was high and the release time was relatively long, so the drug release could be controlled. Moreover, when the gelator concentration was too low, the gel eroded and the hydrogel microspheres could not play the role of the drug release controlling.