利塞膦酸钠油包固混悬剂的制备
Preparation of a solid-in-oil nanosuspension of risedronate sodium
目的 制备利塞膦酸钠油包固（S/O）混悬剂。方法 以高水溶性/低膜透过性药物利塞膦酸钠为模型药物，以蔗糖脂肪酸酯ER290和L1695为表面活性剂，中碳链脂肪三酯（MCT）作为油性基质，制备利塞膦酸钠S/O混悬剂。结果 所制备的油包固混悬剂使利塞膦酸钠的溶出行为呈现为脂肪酶对外油相的降解依赖性，影响药物释放的主要因素是L1695的加入量、药物与表面活性剂的比例。结论 所制备的利塞膦酸钠S/O混悬剂，脂溶性增加，有利于药物的吸收。
Objective The aim of this work was to develop a solid-in-oil nanosuspension (SONS) to improve the oral absorption of risedronate sodium. Methods Risedronate itself is water-solouble at neutral pH, it can be readily nanosuspended in an oil phase via complex formation with sucrose esters (ER290 and L1695 as surfactant). Results From the results obtained, the SONSMCT which exhibited risedronate release was dependent on the lipase degradation of medium-chain triglycerides (MCT), the oil phase. Conclusions the SONSMCT has been shown to be a novel carrier-based delivery system for improving the oral absorption of risedronate.
肖文花、张雪竹、朴洪泽、崔福德、朴洪宇
药学
药剂学利塞膦酸钠S/O混悬剂制备
Pharmaceuticssolid-in-oil nanosuspensionrisedronate sodiumpreparation
肖文花,张雪竹,朴洪泽,崔福德,朴洪宇.利塞膦酸钠油包固混悬剂的制备[EB/OL].(2013-03-07)[2025-08-24].http://www.paper.edu.cn/releasepaper/content/201303-287.点此复制
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