中药对断奶腹泻大鼠的生长性能、器官指数和血液生化指标的影响
Effect of Chinese Herbs on Growth Performance, Visceral Organ Index, and Blood Biochemical Measurement of Rats with Weaning Diarrhea
为探讨中药复方对断奶大鼠腹泻的防治效果,本研究将19日龄断奶大鼠按照2×4因素随机分成8组:经腹泻造模处理的对照组、抗生素组、方Ⅰ组、方Ⅱ组以及未经腹泻处理的对照组、抗生素组、方Ⅰ组、方Ⅱ组,经过腹泻造模处理后,分别灌服无菌生理盐水、硫酸粘杆菌素、方Ⅰ、方Ⅱ。分别于第3、7、14天测定大鼠的平均日采食量、平均日增重、器官指数以及血清生化指标变化。结果表明,方Ⅰ和方Ⅱ均可提高断奶大鼠平均日采食量,且方Ⅱ对大鼠平均日增重和料重比的提高效果优于方Ⅰ;方Ⅰ和方Ⅱ可分别显著提高断奶大鼠肝脏指数和脾脏指数(P<0.05);方Ⅰ和方Ⅱ均可一定程度提高断奶大鼠血清AST活性,降低断奶大鼠血清UREA含量;而硫酸粘杆菌素对所有检测指标均无显著影响(P>0.05)。表明中药复方可有效的提高断奶腹泻大鼠的生长性能和机体免疫能力,促进机体蛋白质合成代谢,并降低蛋白质分解代谢,有利于促进断奶大鼠的生长发育,且以方Ⅱ效果较好。
In order to study the effects of Chinese herbs on prevention diarrhea of weaning rats, the 19-day-old weaning rats were randomly divided into eight groups according to 2×4 factors: control group, antibacterial group, prescription groupⅠ, prescription group Ⅱ with diarrhea treatment included or not. While after the rats in different groups were managed with diarrhea model, the rats were fed with sterile saline, colistin, prescriptionⅠ, prescription Ⅱ in respectively. Then the intake, weight gain, liver index, spleen index, kidney index, small intestine index and serum biochemical parameters in rats were all measured on the 3rd day, 7th day and 14th day. The results showed that prescription groupⅠ and prescription group Ⅱ could increase the intake of 19-day-old weaned rats in significantly (P<0.05), and body weight gain and feed conversion ratio of prescription group Ⅱare more higher than that of prescription group Ⅰ; and the prescription group Ⅰ and Ⅱ can significantly improve weaning rat liver index and spleen index(P<0.05),; prescription group Ⅰ and prescription group Ⅱ could improve the activity of ALT and AST in serum as well as decrease the level of UREA in rats. The colistin has no effects on all measurements. Therefore, Chinese herbs could improve the growth performance and immune function, enhance the Protein synthesis and reduce the Protein catabolism, which is good for the growth of weaned rats.
王自力、涂君平、王明周、陈佳、黎佳颖、蒋甜甜、张翥
中医学医学研究方法基础医学
临床兽医中药断奶大鼠肝脏指数脾脏指数血清生化指标
linical veterinariansChinese medicineweaning ratsliver indexSpleen indexSerum biochemical parameter
王自力,涂君平,王明周,陈佳,黎佳颖,蒋甜甜,张翥.中药对断奶腹泻大鼠的生长性能、器官指数和血液生化指标的影响[EB/OL].(2014-10-07)[2025-08-11].http://www.paper.edu.cn/releasepaper/content/201410-24.点此复制
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