甘露糖通过下调GLUT1抑制结直肠癌发生及增殖

Purpose: to explore the effect of mannose on colorectal tumorigenesis and proliferation, and the mechanism. The mouse model of primary colorectal cancer was established. The intervention of mannose could significantly reduce the incidence and progression of colorectal tumor. In the vitro experiment, through the MTT experiment, it was found that mannose could significantly reduce the proliferation of colorectal cancer cell lines HCT116 and HT29, and after the stimulation concentration of 25 mmol/L, for 48 hours, it could significantly reduce the glucose consumption in the culture medium of the two cell lines, reaching 68.40% and 58.78%, respectively. By Western blotting, it was found that mannose could reduce the expression of glucose transporter protein GLUT1 in these two cell lines, and the same results were obtained in vivo experiment. Conclusion: mannose can interfere with glucose uptake and proliferation of colorectal cancer cells in vitro and reduce the incidence and progression of primary colorectal tumor in mice. It is speculated that this phenomenon is related to the down-regulation of glucose transporter GLUT1 expression.