基于磁性NiCo2O4超级结构的免疫传感器及其对肿瘤标记物的超灵敏检测
Ultrasensitive Sensor for Tumor Marker Based on the Magnetic NiCo2O4 Superstructure
一种新型的无酶生物探针（即血红素功能化的磁性NiCo2O4超级结构(MNS-Hb)）被用于实现对癌胚抗原（CEA）的光电化学和电化学双信号免疫传感。MNS-Hb纳米复合物被发现具有模拟酶的作用，具有很强的催化活性，并能明显地增强电催化信号。该发现对发展超灵敏，成本低以及环境友好型的双信号免疫识别器件的构建具有良好的借鉴意义，并且可实现对肿瘤标记物的准确定量。
new enzyme-free bioprobe, consisted of hematin functioned magnetic NiCo2O4 superstructure (MNS-Hb), was designed for ultrasensitive photoelectrochemical and electrochemical dual-readout immunosensing of carcinoembryonic antigen (CEA) on carbon nanohorns (CNH) support. MNS-Hb nano-hybrid exhibited much higher mimic enzyme catalytic activity and evidently amplified electrocatalytic signal.The experimental outcome demonstrated the promising application of MNS in developing ultrasensitive, cost-effective and environment friendly dual-readout immunosensor and accurate clinical diagnoses strategy for tumor markers.
徐桂芳、张书培、龚玲珊、戴宏、张清榕、李宜霖、严惠湘、陈四红
肿瘤学生物科学研究方法、生物科学研究技术生物化学
磁性NiCo2O4超级结构双信号免疫传感生物探针肿瘤标记物
Magnetic NiCo2O4 superstructureDual-signal immunosensorbioprobetumor marker
徐桂芳,张书培,龚玲珊,戴宏,张清榕,李宜霖,严惠湘,陈四红.基于磁性NiCo2O4超级结构的免疫传感器及其对肿瘤标记物的超灵敏检测[EB/OL].(2015-11-03)[2025-08-18].http://www.paper.edu.cn/releasepaper/content/201511-31.点此复制
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