Effectiveness of vaccines in preventing hospitalization due to COVID-19: A multicenter hospital-based case-control study, Germany, June 2021 to January 2022
Effectiveness of vaccines in preventing hospitalization due to COVID-19: A multicenter hospital-based case-control study, Germany, June 2021 to January 2022
Abstract We included 852 patients in a prospectively recruiting multicenter matched case-control study in Germany to assess vaccine effectiveness (VE) in preventing COVID-19-associated hospitalization (Delta-variant dominance). Two-dose VE was 89% (95%CI 84-93%) overall, 79% in patients with >2 comorbidities and 77% in adults aged 60-75 years. A third dose increased VE to >93% in all patient-subgroups.
Hildt Eberhard、Gl?ser Sven、Ghouzi Ammar、Schaade Lars、Herath Tim、Lachmann Johannes、Nitsche Andreas、Michel Janine、Hofmann Natalie、Brinkmann Annika、Sch¨1hlen Helmut、Peric Alexander、Reichardt Annette、Lock Guntram、Stern Daniel、Kohl Claudia、Rinner Thomas、D?rre Achim、Stoliaroff-Pepin Anna、Peine Caroline、Janneck Matthias、Harder Thomas、Meyer Tanja、Werel Laura、Isner Caroline、Hein Sascha、Grossegesse Marica、Perriat Delphine、Wichmann Ole、Dorner Brigitte G.、Treindl Fridolin
Division Virology, Paul-Ehrlich-InstituteKlinik f¨1r Innere Medizin - Pneumologie und Infektiologie, Vivantes Klinikum Neuk?lln und SpandauSch?n Klinik D¨1sseldorf, Interdisziplin?re NotaufnahmeCentre for Biological Threats and Special PathogensDepartment for Infectious Disease Epidemiology, Immunization Unit, Robert Koch InstituteDepartment for Infectious Disease Epidemiology, Immunization Unit, Robert Koch InstituteCentre for Biological Threats and Special Pathogens, ZBS1 Highly Pathogenic Viruses, Robert Koch InstituteCentre for Biological Threats and Special Pathogens, ZBS1 Highly Pathogenic Viruses, Robert Koch InstituteCentre for Biological Threats and Special Pathogens, ZBS1 Highly Pathogenic Viruses, Robert Koch InstituteCentre for Biological Threats and Special Pathogens, ZBS1 Highly Pathogenic Viruses, Robert Koch InstituteVivantes Netzwerk f¨1r Gesundheit GmbH, Direktorat Klinische Forschung & Akademische LehreKlinik f¨1r Pneumologie und Infektiologie, Vivantes Klinikum im FriedrichshainHelios Klinikum Berlin-BuchKlinik f¨1r Innere MedizinCentre for Biological Threats and Special Pathogens, ZBS3 Biological Toxins, Robert Koch InstituteCentre for Biological Threats and Special Pathogens, ZBS1 Highly Pathogenic Viruses, Robert Koch InstituteCentre for Biological Threats and Special Pathogens, ZBS1 Highly Pathogenic Viruses, Robert Koch InstituteDepartment for Infectious Disease Epidemiology, Robert Koch InstituteDepartment for Infectious Disease Epidemiology, Immunization Unit, Robert Koch InstituteDepartment for Infectious Disease Epidemiology, Immunization Unit, Robert Koch InstituteKlinik f¨1r Kardiologie, Sektion NephrologieDepartment for Infectious Disease Epidemiology, Immunization Unit, Robert Koch InstituteCentre for Biological Threats and Special Pathogens, ZBS3 Biological Toxins, Robert Koch InstituteDivision Virology, Paul-Ehrlich-InstituteKlinik f¨1r Innere Medizin - Infektiologie, Vivantes Auguste-Viktoria-KlinikumDivision Virology, Paul-Ehrlich-InstituteCentre for Biological Threats and Special Pathogens, ZBS1 Highly Pathogenic Viruses, Robert Koch InstituteDepartment for Infectious Disease Epidemiology, Immunization Unit, Robert Koch InstituteDepartment for Infectious Disease Epidemiology, Immunization Unit, Robert Koch InstituteCentre for Biological Threats and Special Pathogens, ZBS3 Biological Toxins, Robert Koch InstituteCentre for Biological Threats and Special Pathogens, ZBS3 Biological Toxins, Robert Koch Institute
预防医学医学研究方法医药卫生理论
COVID-19vaccine effectivenesshospitalizationcase-control studySARS-CoV-2Delta
Hildt Eberhard,Gl?ser Sven,Ghouzi Ammar,Schaade Lars,Herath Tim,Lachmann Johannes,Nitsche Andreas,Michel Janine,Hofmann Natalie,Brinkmann Annika,Sch¨1hlen Helmut,Peric Alexander,Reichardt Annette,Lock Guntram,Stern Daniel,Kohl Claudia,Rinner Thomas,D?rre Achim,Stoliaroff-Pepin Anna,Peine Caroline,Janneck Matthias,Harder Thomas,Meyer Tanja,Werel Laura,Isner Caroline,Hein Sascha,Grossegesse Marica,Perriat Delphine,Wichmann Ole,Dorner Brigitte G.,Treindl Fridolin.Effectiveness of vaccines in preventing hospitalization due to COVID-19: A multicenter hospital-based case-control study, Germany, June 2021 to January 2022[EB/OL].(2025-03-28)[2025-05-24].https://www.medrxiv.org/content/10.1101/2022.06.28.22276303.点此复制
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