胎盘小叶胎儿血管系统促肾上腺皮质激素释放激素及其受体CRH-R1的表达

bjective To study expression of corticotropin-releasing hormone and its receptor type-1 in the placental cotyledon vessels at term. Methods This study has used IHC-SP staining and ISH methods to investigate the expression patterns of CRH and its receptor CRH-R1 in the placental cotyledon vessels at term from women who have undergone uncomplicated pregnancies. Placental tissues were collected after cesarian section before threatened labor. Results Our study shows for the first time that endothelial cells and even smooth muscle cells of the cotyledon vessel express CRH messenger ribonucleic acid and peptide as well as the CRH-R1. Conclusion Novel findings are presented on that CRH derived from endothelial cells and even smooth muscle cells of the cotyledon vessel may represent the main source of CRH levels in fetal plasma. There is the ability of mobilizing compensation mechanism quickly to adapt to the acute stress by CRH derived from endothelial cells and even smooth muscle cel