Potent but transient immunosuppression of T-cells is a general feature of erythroid progenitor cells
Potent but transient immunosuppression of T-cells is a general feature of erythroid progenitor cells
Abstract Erythroid progenitor cells (EPCs) have been recently recognized as potent immunoregulatory cells with defined roles in fetomaternal tolerance and immune response to infectious agents in neonates and cancer patients. Here, we show that early-stage EPCs are enriched in anemia, have high levels of arginase 2 (ARG2) and reactive oxygen species (ROS). EPCs expansion in anemic mice leads to the L-arginine depletion in the spleen microenvironment resulting in the suppression of T-cell responses. In humans with anemia, EPCs expand and express both ARG1 and ARG2 that participate in suppressing the proliferation and production of IFN-γ from T-cells. EPCs differentiated from peripheral blood mononuclear cells potently suppress T-cell proliferation and this effect is the most prominent for CD49dhi CD71hiEPCs. The suppressive properties disappear during erythroid differentiation as more differentiated EPCs as well as mature erythrocytes lack significant immunoregulatory properties. Our studies provide a novel insight into the role of EPCs in the regulation of immune response. biorxiv;2021.01.18.427109v1/UFIG1F1ufig1
Grzywa Tomasz M.、Sosnowska Anna、Malecka Milena、Ciepiela Olga、Wegrzynowicz Michal、Tomaszewska Agnieszka、Basak Grzegorz、Rodziewicz-Lurzynska Anna、Pomper Paulina、Plewczynski Dariusz、Lazniewski Michal、Blaszczyk Roman、Rydzynska Zuzanna、Justyniarska Magdalena、Grzybowski Marcin M.、Golab Jakub、Klicka Klaudia、Nowis Dominika
Department of Immunology, Medical University of Warsaw||Doctoral School of the Medical University of Warsaw||Laboratory of Experimental Medicine, Medical University of WarsawDepartment of Immunology, Medical University of Warsaw||Postgraduate School of Molecular Medicine, Medical University of WarsawDepartment of Laboratory Medicine, Medical University of WarsawDepartment of Laboratory Medicine, Medical University of WarsawLaboratory of Molecular Basis of Neurodegeneration, Mossakowski Medical Research Institute, Polish Academy of SciencesDepartment of Hematology, Transplantation and Internal Medicine, Medical University of WarsawDepartment of Hematology, Transplantation and Internal Medicine, Medical University of WarsawCentral Laboratory, University Clinical Center of Medical University of WarsawOncoArendi TherapeuticsLaboratory of Functional and Structural Genomics, Centre of New Technologies, University of Warsaw||Faculty of Mathematics and Information Science, Warsaw University of TechnologyLaboratory of Functional and Structural Genomics, Centre of New Technologies, University of Warsaw||Centre for Advanced Materials and Technologies, Warsaw University of TechnologyOncoArendi TherapeuticsDepartment of Immunology, Medical University of WarsawDepartment of Immunology, Medical University of WarsawOncoArendi TherapeuticsDepartment of Immunology, Medical University of Warsaw||Centre of Preclinical Research, Medical University of WarsawDoctoral School of the Medical University of Warsaw||Department of Methodology, Medical University of WarsawDepartment of Immunology, Medical University of Warsaw||Laboratory of Experimental Medicine, Medical University of Warsaw
基础医学生物科学研究方法、生物科学研究技术分子生物学
erythroid progenitor cellsanemiaarginasereactive oxygen speciesimmunosuppressionphenylhydrazine
Grzywa Tomasz M.,Sosnowska Anna,Malecka Milena,Ciepiela Olga,Wegrzynowicz Michal,Tomaszewska Agnieszka,Basak Grzegorz,Rodziewicz-Lurzynska Anna,Pomper Paulina,Plewczynski Dariusz,Lazniewski Michal,Blaszczyk Roman,Rydzynska Zuzanna,Justyniarska Magdalena,Grzybowski Marcin M.,Golab Jakub,Klicka Klaudia,Nowis Dominika.Potent but transient immunosuppression of T-cells is a general feature of erythroid progenitor cells[EB/OL].(2025-03-28)[2025-05-06].https://www.biorxiv.org/content/10.1101/2021.01.18.427109.点此复制
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