Long-range phase synchronization of high-gamma activity in human cortex
Long-range phase synchronization of high-gamma activity in human cortex
Abstract Inter-areal neuronal phase synchronization is thought to involve oscillations below 100 Hz while faster oscillations are presumed to be coherent only in local circuits. We show with human intracerebral recordings that 100–300 Hz high-gamma activity (HGA) can be phase synchronized between widely distributed regions. HGA synchronization was neither attributable to physiological and technical artefacts nor to epileptic pathophysiology, e.g., it was as prevalent in areas distant from the epileptic zone as within. HGA phase synchronization exhibited a reliable large-scale connectivity and cortex-wide community structures. Moreover, HGA synchronization displayed a laminar profile opposite to that of low-frequency oscillations by being stronger between the deep than the superficial cortical layers. Hence HGA synchronization constitutes a novel and temporally highly accurate form of consistent timing relationships in large-scale human cortical activity. We suggest that HGA synchronization elucidates the temporal microstructure of spiking-based neuronal communication per se in cortical circuits.
Arnulfo G、Cardinale F、Zhigalov A、Palva S、Rubino A、Hirvonen J、Williams N、Fato MM、Palva JM、Nobili L、Wang SH
Neuroscience Center, Helsinki Institute of Life Science, University of Helsinki||Dept. of Informatics, Bioengineering, Robotics and System engineering, University of Genoa?°Claudio Munari?± Epilepsy Surgery Centre, Niguarda HospitalNeuroscience Center, Helsinki Institute of Life Science, University of HelsinkiNeuroscience Center, Helsinki Institute of Life Science, University of Helsinki||BioMag laboratory, HUS Medical Imaging Center||Center for Cognitive Neuroimaging, Institute of Neuroscience and Psychology, University of Glasgow?°Claudio Munari?± Epilepsy Surgery Centre, Niguarda HospitalNeuroscience Center, Helsinki Institute of Life Science, University of Helsinki||Doctoral Programme Brain & Mind, University of HelsinkiNeuroscience Center, Helsinki Institute of Life Science, University of HelsinkiDept. of Informatics, Bioengineering, Robotics and System engineering, University of GenoaNeuroscience Center, Helsinki Institute of Life Science, University of Helsinki||Center for Cognitive Neuroimaging, Institute of Neuroscience and Psychology, University of Glasgow?°Claudio Munari?± Epilepsy Surgery Centre, Niguarda Hospital||Child Neuropychiatry, G. Gaslini Institute, DINOGMI, University of GenoaNeuroscience Center, Helsinki Institute of Life Science, University of Helsinki||Doctoral Programme Brain & Mind, University of Helsinki||BioMag laboratory, HUS Medical Imaging Center
生物物理学
ripplehigh gamma activityhigh-frequency oscillationssynchronizationfunctional connectivityepilepsy
Arnulfo G,Cardinale F,Zhigalov A,Palva S,Rubino A,Hirvonen J,Williams N,Fato MM,Palva JM,Nobili L,Wang SH.Long-range phase synchronization of high-gamma activity in human cortex[EB/OL].(2025-03-28)[2025-05-28].https://www.biorxiv.org/content/10.1101/442251.点此复制
评论