环状RNA（CircRNA）及其与YAP在肿瘤中的研究进展
ircular RNA (CircRNA) and YAP in tumor:a Review
背景：环状 RNA（circular Ribonucleic Acid，circRNA）是近年来发现的一类在真核细胞中广泛存在的闭合环形结构的RNA。 现状：circRNA性质稳定，具有高度的保守性及组织和疾病特异性，在转录或转录后水平调控靶基因表达，与肿瘤的发生、发展相关。YAP（Yes-associated protein）是Hippo信号通路（Hippo signaling pathway）的主要效应子，研究发现YAP水平与细胞增殖和凋亡，组织器官大小的控制以及肿瘤发生等多种过程紧密相关。 用途：研究circRNA与YAP在肿瘤中的相关性意义重大。
????? Background: Circular Ribonucleic Acid (circRNA) is a type of RNA that has been found in recent years and is a closed loop structure widely found in eukaryotic cells. Present situation: The circRNA is stable in nature, highly conserved and tissue and disease specific, and regulates target gene expression at the transcriptional or posttranscriptional level, which is related to the occurrence and development of tumors. YAP (Yes-associated protein) is the main effector of Hippo signaling pathway. It is found that YAP level is closely related to cell proliferation and apoptosis, tissue organ size control and tumorigenesis. Aim: to study the correlation between circRNA and YAP in tumors.
田晓东、梁桢桢、于海云、徐晓慧、李旭、牟向东
肿瘤学基础医学分子生物学
肿瘤circRNAYAP。
tumorcircRNAYAP.
田晓东,梁桢桢,于海云,徐晓慧,李旭,牟向东.环状RNA（CircRNA）及其与YAP在肿瘤中的研究进展[EB/OL].(2019-02-19)[2025-05-05].http://www.paper.edu.cn/releasepaper/content/201902-49.点此复制
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