水基复合抗菌剂羧甲基壳聚糖银噻苯咪唑的抗菌性能及其尺寸效应

Four aqueous complex agents of Ag-Carboxymethyl chitosan-thiabendazole (Ag-CMCTS-TBZ) were prepared using Carboxymethyl chitosans synthesized from chitosans with molecular weights (MWs) of 72.4, 166, 305 and 400 kDa respectively. Potentiometric titration, UV-vis spectrometry, FT-IR spectroscopy, ZetaPlus particle size analyzing and minimum inhibitory concentration (MIC) assessment were used to characterize them. The results showed that the four aqueous complex agents presented broad spectrum of antimicrobial activity with MICs ranging from 30 to 125 mg/L for bacteria Escherichia coli, Staphylococcus aureus and yeast Candida albicans and 100-1800 mg/L for fungi Aspergillus niger, Mucor sp., and the smaller apparent diameter of the aqueous complex agents within the range of 365-1229 nm did not certainly lead to better antimicrobial activity. The univariate analysis of variance further confirmed no significant difference in antimicrobial activity among the four agents. These agents are more convenient for application to water-based acrylic latex coatings, compared to the solid Ag-CMCTS-TBZ formulation in our previous study.