慢性阻塞性肺疾病患者营养状态与血浆生长素释放肽水平的相关性

Objective To understand the relationship of patients with chronic obstructive pulmonary disease(COPD) betweenplasma Ghrelin level , degree of malnutrition and severity of disease. Methods Test plasma Ghrelin level of 80 COPD patientsof stable stage were divided into malnutrition group 42 cases and normal nutrition group 38 cases and 32 healthy controllerswere analysed by the method of radioimmunoassay. Enzyme-linked immunosorbent assay method was used to test tumornecrosis factor-1, Leukocyte interleukin-1, and bioelectrical impedance was used to test body adipose composition analysis.Body mass index, triceps skin fold thickness ,middle arm circumference and serum albumin were tested. The relationship ofplasma Ghrelin level, nutrition and cytokines were analysed. Results The plasma Ghrelin of malnutrition COPD group washigher than that of normal nutrition group and healthy controls(P<0.01), so was to the cytokines level(P<0.01). The plasmaGhrelin level was negatively related to most nutritional index(P0.05). Conclusion The higher level of Ghrelin of COPD patients, the more severe the patientwas and the worse nutrition with more severer inflammation response.