地塞米松加重OPG缺乏引发的骨质疏松

【Objective】 To study the effect of OPG on osteoclast in glucocorticoid-induced osteoporosis. 【Methods】 Dexamethasone was injected intraperitoneally into OPG knockout mice and wild type mice. HE staining and TRAP staining were used to observe the changes of bone mass and osteoclasts in femoral trabeculae and cortical area. 【Results】 Dexamethasone resulted in decreased bone mass of trabecular and cortical bone in mice. In the absence of OPG conditions, dexamethasone caused bone mass decreased more significantly, the number of osteoclasts increased significantly. 【Conclusion】 OPG reduces the loss of bone mass and inhibits the number of osteoclasts in dexamethasone-induced osteoporosis in mice. OPG suppression may contribute to glucocorticoids induced osteoporosis.