胸腰椎爆裂骨折相邻椎间盘组织病理学改变的对比分析

objective to compare the injury extents of superior and inferior disc tissues of burst fracture and discuss the possible pathologic mechanism of the post-traumatic disc changes. Methods to collect the superior and inferior disc tissues in 24 patients during operation . HE, Alcian blue staining, Immunohitochemistry(IHC) were performed. Experimental data were analysed with Photoshop8.0, Image-Pro Plus and SPSS13.0. Results By using immunohistochemistry IL-1β was expressed in the matrix around the end-plate cartilage cells and iNOS was expressed in the cartilage cells. superior disk end-plate are more apt to injury in burst fracture. injuties in superior disc adjacent to the involved vertebra was more severe the content of proteoglycan and decreased sharply in superior discs compared to inferior discs(p=0.005，p=0.04<0.05). Conclusions In thoracolumbar burst fracture, By molecular pathologic measurement the superior disk end-plate are more apt to injury in burst fracture. As the different expressions of the two proteins between the degenerative disk and injury disk were concerned, we suspect that there exist some different pathologic mechanism while the disk was injuried.