Serum level of High-density lipoprotein particles are independently associated with long-term prognosis in patients with coronary artery disease: The GENES study
Serum level of High-density lipoprotein particles are independently associated with long-term prognosis in patients with coronary artery disease: The GENES study
Abstract BACKGROUNDHDL-Cholesterol (HDL-C) is not an accurate surrogate marker to measure the cardioprotective functions of HDL in coronary artery diseases (CAD) patients. Hence, measurement of other HDL-related parameters may have prognostic superiority over HDL-C. OBJECTIVEThis work aimed to examine the predictive value of HDL particles profile for long-term mortality in CAD patients. Its informative value was compared to that of HDL-C and apoA-I. METHODSHDL particles profile were measured by nuclear magnetic resonance (NMR) spectroscopy in 214 male participants with stable CAD (45-74 years). Median follow up was 12.5 years with a 36.4% mortality rate. Cardiovascular mortality accounted for 64.5 %. RESULTSMean concentrations of total HDL particles (HDL-P), small-sized HDL (SHDL-P) and apoA-I were lower in deceased than in surviving patients whereas no difference was observed according to HDL-C and large HDL particles. All NMR-HDL measures were correlated between themselves and with other HDL markers (HDL-C, apoA-I and LpA-I). In a multivariate model adjusted for 14 cardiovascular risk factors and bioclinical variables, HDL-P and SHDL-P displayed the strongest inverse association with all-cause and cardiovascular mortality. Weaker associations were recorded for apoA-I. CONCLUSIONHDL particle profile measured by NMR spectroscopy should be considered to better stratify risk in population at high risk or in the setting of pharmacotherapy.
Genoux Annelise、Ferrieres Jean、Perret Bertrand、Martinez Laurent O.、Ingueneau C¨|cile、Najib Souad、Duparc Thibaut、Ruidavets Jean-Bernard
Institut National de la Sant¨| et de la Recherche M¨|dicale (INSERM), UMR 1048, Institute of Metabolic and Cardiovascular Diseases||University of Toulouse, UMR1048||Service de Biochimie, P?le biologie, H?pital de PurpanDepartment of Epidemiology, Health Economics and Public Health, UMR1027 INSERM, Toulouse University||F¨|d¨|ration de Cardiologie, Toulouse University HospitalInstitut National de la Sant¨| et de la Recherche M¨|dicale (INSERM), UMR 1048, Institute of Metabolic and Cardiovascular Diseases||University of Toulouse, UMR1048||Service de Biochimie, P?le biologie, H?pital de PurpanInstitut National de la Sant¨| et de la Recherche M¨|dicale (INSERM), UMR 1048, Institute of Metabolic and Cardiovascular Diseases||University of Toulouse, UMR1048Institut National de la Sant¨| et de la Recherche M¨|dicale (INSERM), UMR 1048, Institute of Metabolic and Cardiovascular Diseases||University of Toulouse, UMR1048||Service de Biochimie, P?le biologie, H?pital de PurpanInstitut National de la Sant¨| et de la Recherche M¨|dicale (INSERM), UMR 1048, Institute of Metabolic and Cardiovascular Diseases||University of Toulouse, UMR1048Institut National de la Sant¨| et de la Recherche M¨|dicale (INSERM), UMR 1048, Institute of Metabolic and Cardiovascular Diseases||University of Toulouse, UMR1048Department of Epidemiology, Health Economics and Public Health, UMR1027 INSERM, Toulouse University
医药卫生理论医学研究方法内科学
high density lipoproteinapolipoprotein A-Icholesterolbiomarkerrisk managementcoronary artery disease
Genoux Annelise,Ferrieres Jean,Perret Bertrand,Martinez Laurent O.,Ingueneau C¨|cile,Najib Souad,Duparc Thibaut,Ruidavets Jean-Bernard.Serum level of High-density lipoprotein particles are independently associated with long-term prognosis in patients with coronary artery disease: The GENES study[EB/OL].(2025-03-28)[2025-08-02].https://www.biorxiv.org/content/10.1101/676122.点此复制
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