基于镁铝水滑石纳米片载药系统的研制并应用于癌症细胞的治疗

he p53 protein encoded by the Tp53 gene, as an important tumor suppressor, plays a key role in preventing the occurrence of tumors.Mutant p53（Mutp53）can promote the growth, proliferation, invasion and metastasis of tumor cells while losing the original anti-cancer activity.In addition, studies have shown that Mutp53 needs to form a molecular chaperone complex with HSP90 to maintain its protein structure stability. Therefore, we propose to deliver a highly catalytically active Glucose oxidase (GOx) by inorganic nanoparticles（MgAl-LDH）into Mutp53 tumor cells to reduce the supply of intracellular ATP by catalytically decomposing Glucose. The results showed that the nanoparticles was homogeneous and stable and could effectively enter the cell and successfully achieve lysosome escape and cause obvious killing to the Mutp53 cells. This method provides a novel and promising therapeutic approach for the treatment of cancer cells based on Mutp53 type.