Short-Term Evolution and Dispersal Patterns of Fluconazole-Resistance in Candida auris Clade III
Short-Term Evolution and Dispersal Patterns of Fluconazole-Resistance in Candida auris Clade III
ABSTRACT The rapid increase of infections caused by the emerging fungal pathogen Candida auris is of global concern, and understanding its expansion is a priority. The phylogenetic diversity of the yeast is clustered in five major clades, among which clade III is particularly relevant, as most of its strains exhibit resistance to fluconazole, reducing the therapeutic alternatives and provoking outbreaks that are difficult to control. In this study, we have investigated the phylogenetic structure of clade III by analyzing a global collection of 566 genomes. We have identified three subgroups within clade III, among which two are genetically most closely related. Moreover, we have estimated the evolutionary rate of clade III to be 2.25e-7 substitutions/site/year (2.87 changes per year). We found that one of these subgroups shows intrinsic resistance to fluconazole and is responsible for the majority of cases within this clade globally. We inferred that this subgroup may have originated around December 2010 (95% CI: April 2010 - June 2011), and since then it has spread across continents, generating multiple large outbreaks, each with a unique pattern of transmission and dissemination. These results highlight the remarkable ability of the pathogen to adapt to its environment and its rapid global spread, underscoring the urgent need to effectively address this epidemiological challenge.
Gimeno-Cardona Concepci¨?n、Tormo-Palop Nuria、Gonz¨￠lez-Candelas Fernando、Cancino-Mu?oz Irving、Mulet-Bayona Juan Vicente、Salvador-Garc¨aa Carme、Guna Remedios
Servicio de Microbiolog¨aa y Parasitolog¨aa, Consorcio Hospital General Universitario de ValenciaServicio de Microbiolog¨aa y Parasitolog¨aa, Consorcio Hospital General Universitario de ValenciaUnidad Mixta Infecci¨?n y Salud P¨2blica FISABIO-Universidad de Valencia||Instituto de Biolog¨aa Integrativa de Sistemas, I2SysBio (CSIC-UV)||CIBER en Epidemiolog¨aa y Salud P¨2blica, ISCIIIUnidad Mixta Infecci¨?n y Salud P¨2blica FISABIO-Universidad de Valencia||Instituto de Biolog¨aa Integrativa de Sistemas, I2SysBio (CSIC-UV)Servicio de Microbiolog¨aa y Parasitolog¨aa, Consorcio Hospital General Universitario de ValenciaServicio de Microbiolog¨aa y Parasitolog¨aa, Consorcio Hospital General Universitario de ValenciaServicio de Microbiolog¨aa y Parasitolog¨aa, Consorcio Hospital General Universitario de Valencia
微生物学医学研究方法医药卫生理论
Fungal pathogenCandida aurisFluconazole resistancephylogenetic structureDispersion
Gimeno-Cardona Concepci¨?n,Tormo-Palop Nuria,Gonz¨￠lez-Candelas Fernando,Cancino-Mu?oz Irving,Mulet-Bayona Juan Vicente,Salvador-Garc¨aa Carme,Guna Remedios.Short-Term Evolution and Dispersal Patterns of Fluconazole-Resistance in Candida auris Clade III[EB/OL].(2025-03-28)[2025-08-02].https://www.biorxiv.org/content/10.1101/2024.05.22.595305.点此复制
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