非正常态氮杂卡宾催化的分子内醛腈偶联反应

N-heterocyclic carbene ligands have been widely used either in the metal coordination chemistry and organometallic catalysis, or in the direct catalytic reactions of small molecules. To synthesis stable and high catalytic activity of N-heterocyclic carbene catalyst has an important theoretical significance and practical value. Due to the special structures of abnormal N-heterocyclic carbenes, compared to the normal NHCs, the abnormal N-heterocyclic carbenes have different catalytic properties in metal-catalysis and organic catalysis. Abnormal N-heterocyclic carbene precursor were chosen and studied by us. A series of abnormal N-heterocyclic carbene precursor were prepared in this paper, and their application in the intramolecular coupling reaction of aldehyde nitrile were studied. Under optimal conditions, up to 93% yield can be obtained.