铁死亡在非小细胞肺癌中的肿瘤抑制作用
Ferroptosis in non-small cell lung cancer
铁死亡是一种铁依赖性的脂质过氧化物积累引起的不同于凋亡、坏死和自噬的新的细胞死亡方式。通过筛选多种不同癌细胞对erastin的敏感性，发现非小细胞肺癌细胞A549、H1299对铁死亡非常敏感。检测两种细胞在加入erastin后胞内ROS显著升高。在利用多种抑制剂验证铁死亡模型成功后，构建非小细胞肺癌A549移植瘤模型，发现erastin在非小细胞肺癌A549移植瘤中具有一定的肿瘤抑制作用。
Ferroptosis,a result from iron-dependent lipid peroxide accumulation, is a unique cell death which is distinct from apoptosis, necrosis, and autophagy . Screening for the sensitivity of several different cancer cells to erastin found that non-small cell lung cancer cells A549, H1299 are very sensitive to Ferroptosis. The intracellular ROS significantly increased after adding erastin. A non-small cell lung cancer A549 xenograft model was constructed and it was found that erastin has a certain tumor suppressing effect.
付国玲、单锴、陈永泉、王春梅
肿瘤学基础医学细胞生物学
铁死亡非小细胞肺癌肿瘤抑制???
ferroptosisnon-small cell lung cancertumor suppression????
付国玲,单锴,陈永泉,王春梅.铁死亡在非小细胞肺癌中的肿瘤抑制作用[EB/OL].(2018-03-23)[2025-08-02].http://www.paper.edu.cn/releasepaper/content/201803-209.点此复制
评论