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九种神经支架材料的力学指标测试

study on mechanics property of materials as candidated nerver scaffold

中文摘要英文摘要

背 景 组织工程支架都需要有一定的力学性能以满足实际使用时的要求。目 的 考察9种候选神经支架材料的力学性能,为神经支架的设计制作的选材提供力学依据。方 法以PLGA、胶原、海藻酸钠、脱细胞猪皮、脱细胞血管,脱细胞猪皮-PLGA的复合体、脱细胞血管-PLGA的复合体以及经改性的壳聚糖和明胶作为考察材料,用拉伸实验机对其进行拉伸试验。结 果 本试验获得了这9种材料的最大应变、最大应力及杨氏模量。结 论 本实验结果为神经支架的选材、设计和制作提供了力学参考依据。

Background Tissue engneering scaffolds must possess suitable mechanics. Objective We investigated the mechanical property of nine materials candidated as nerve scaffold,which could supply an mechanical basis for neuro-scaffold in selecting materials and designing improvement schedule. which can be used as neuro-scaffold from acknowledged fine-biocompatible materials and investigated their tensile strength .They are poly (DL-lactic-co-glycolic acid) (PLGA), sodium polymannuronate, gelatine, chitosan, collogen, acellular pigskin, acellular vascular, acellular-pigskin-PLGA ,acellular-vascular-PLGA .Method. nine materials mentioned above were investigated about their mechanical character .Result the average ultimate-straining of PLGA is the greatest, while that of gelatine is the least; the average ultimate-stress of complex of acellular porcine dermis and PLGA is the greatest ,while that of collage is the least.Conclusion This experimental result can supply a mechanical reference for nerve scaffold in selecting material and designing.

李校堃、麻开旺、刘彬、蔡绍晖、戴小珍、徐志玲、蔡绍皙

基础医学材料科学生物工程学

PLGA明胶壳聚糖胶原神经支架

PLGAgelatinechitosanollogenNeuro-scaffold

李校堃,麻开旺,刘彬,蔡绍晖,戴小珍,徐志玲,蔡绍皙.九种神经支架材料的力学指标测试[EB/OL].(2006-08-02)[2025-05-09].http://www.paper.edu.cn/releasepaper/content/200608-34.点此复制

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