依托咪酯被碱性KMnO4氧化的动力学和光谱学研究
n Anesthetic agent - Etomidate, Oxidation by KMnO4 using alkaline medium: A kinetic and spectroscopic approach
麻醉剂依托咪酯被碱介导的高锰酸钾氧化，并借助紫外-可见分光光度计在恒定离子强度0.01 mol dm-3下研究了氧化速率，化学计量比为1：1。 对于氧化剂和还原剂，相对于碱性介质是伪一级和分数级。 关于速率确定步骤的各种激活参数，例如Ea（kJ / mol），标准摩尔焓（kJ / mol），标准摩尔熵（J / K / mol）和标准摩尔吉布斯自由能（kJ / mol），并且还计算了热动力学量 。 慢速步骤是速率确定步骤，为其计算速率常数并推导机理。
he anesthetic agent etomidate was oxidized by alkaline mediated potassium permanganate and the rate of oxidation was studied with the help of UV-VIS spectrophotometer at constant ionic strength 0.01 mol dm-3 which exhibited a stoichiometry of 1:1. With respect to oxidant and reductant it is pseudo first order and fractional order with respect to alkaline medium. Various activation parameters with respect to rate determining steps like Ea (kJ/mol), ΔHθ (kJ/mol), ΔSθ(J/K/mol) and ΔGθ (kJ/mol) were calculated and thermodyanamic quantities are also calculated. The slow step is the rate determining step for which the rate constant was calculated and mechanism derived.
徐晓源、杜明霞、王玉、林惠珍、张斯博、黄靖
药学化学
动力学氧化依托咪酯高锰酸根离子
KineticsOxidationetomidatePermanganate ion
徐晓源,杜明霞,王玉,林惠珍,张斯博,黄靖.依托咪酯被碱性KMnO4氧化的动力学和光谱学研究[EB/OL].(2020-03-05)[2025-08-30].http://www.paper.edu.cn/releasepaper/content/202003-39.点此复制
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