免疫调控在酒精性肝病治疗中的作用研究
he role of immune regulation in the treatment of alcoholic fatty liver disease
目的：通过益生菌混合物调控机体自身免疫功能来减轻酒精性脂肪肝病（ALD）的发展。方法：本研究拟利用经过功能筛选的益生菌混合物，对ALD模型小鼠进行3个月的干预治疗。通过分析血清生化指标及肝脏组织病理切片，评估实验动物的肝损伤情况和脂质积累情况。另外分别对肝脏、脾脏和肠系膜淋巴结中各种免疫细胞组分的比例进行流式分析。结果：益生菌混合物对ALD模型小鼠的肝损伤有不同程度的保护作用，同时对小鼠各脏器的免疫状态也有一定程度的影响。
Objective: Regulating the immune state of mice with probiotics to reduce the development of alcoholic fatty liver disease (ALD) . Methods: The ALD mice were treated with functional screening probiotics mixture for 3 months. Hepatic fat accumulation, liver injury and inflammation were assessed by biochemical indicators in serum and pathological sections of liver. Systemic and tissue specific immune cell phenotypes were determined byFlow CytoMetry. Results: The administration of probiotics alleviated theliver injury of mice. Probiotics can regulate the immune status of various organs in mice.
刘青青、公丕旭、宗海英、龙乔明、孙娇娇
医药卫生理论基础医学生物科学研究方法、生物科学研究技术
细胞生物学酒精性肝病肝脏免疫肠道免疫益生菌
ytobiologylcoholic fatty liver diseasesLiver immunityGut immunityProbiotics
刘青青,公丕旭,宗海英,龙乔明,孙娇娇.免疫调控在酒精性肝病治疗中的作用研究[EB/OL].(2023-02-09)[2025-08-11].http://www.paper.edu.cn/releasepaper/content/202302-47.点此复制
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