PGE2 通过 EP2 受体调控 IgE 型抗体分泌参与哮喘疾病

im: As chronic respiratory disease, asthma representing severe problems for world public health is currently the major leading cause of death, and it has been proved that elevated prostaglandin E2 (PGE2) concentration can be detected in serum and sputum of patients with asthma, suggesting intimate relationship between these two factors. The aim of current study is to explore the influence of PGE2 on asthma. Methods: Based on the OVA-induced asthma model, the fundemental effect of EP2 deficiency was fully examined in vivo and in vitro. Results: the IgE concentration in serum from EP2 knockout mice(EP2 KO mice) was detected much lower than wildtype. In vitro experiment result suggested that its B cells cannot be stimulated and secreted IgE antibody effecienctly. In vivo study, compared with wild type mice, EP2 knockout mice (EP2 KO mice) had a significantly lower total IgE and OVA-specific IgE in their serum. Moreover, EP2 KO mice didn't have airway hyperresponse as well as the pathological change of their lung tissure was mild. Conclusion: the PGE2-EP2 pathway was an important positive modulator of allergic reactions and IgE production.