Sodium-glucose cotransporter 2-associated perioperative ketoacidosis: a protocol for SAPKA systematic review
Sodium-glucose cotransporter 2-associated perioperative ketoacidosis: a protocol for SAPKA systematic review
Abstract BackgroundIn recent years, reports have increased regarding patients treated with sodium-glucose cotransporter 2 inhibitors (SGLT2i) who develop severe ketoacidosis during the perioperative period. This systematic review aims to extrapolate precipitating factors from case reports of SGLT2i-associated perioperative ketoacidosis. MethodsTwo independent researchers will search PubMed, EMBASE, and Web of Science, up to June 1, 2022, with no language restrictions, to identify reports of perioperative ketoacidosis associated with SGLT2i use. We will include case reports/series describing patients taking SGLT2i who developed ketoacidosis (defined as blood pH < 7.3 and blood or urine ketone positivity) pre-, intra-, or postoperatively up to 30 days following surgery. Patients for whom SGLT2i was newly prescribed postoperatively and those for whom the diagnosis of ketoacidosis does not fulfill our criteria will be excluded. Competing interest statementDr. Yasuda reports receiving grants from Ono Pharmaceutical and Mitsubishi Tanabe Pharma Corporation. Funding statementThe Japan Society for the Promotion of Science Grant-in-Aid for Scientific Research (C) (Grant Number 21K06676) funded this study.
Hoshijima Hiroshi、Motoyasu Akira、Kondo Kazuya、Yoshikawa Takahiro、Hyuga Shunsuke、Nagai Ai、Ono Motoaki、Ideno Satoshi、Ouchi Takashi、Yasuda Kazuki、Kuratani Norifumi、Seki Hiroyuki、Higashi Midoriko、Noguchi Hikari、Shishii Miho、Shiga Toshiya、Watanabe Hidenobu
Division of Dento-oral Anesthesiology, Tohoku University Graduate School of DentistryDepartment of Anesthesiology, Kyorin University School of MedicineDepartment of Anesthesiology, Kyorin University School of MedicineDepartment of Anesthesiology, Kyorin University School of MedicineDepartment of Anesthesiology, Kitasato University School of MedicineDepartment of Anesthesiology, Kitasato University School of MedicineDepartment of Anesthesiology, Kyorin University School of MedicineDepartment of Anesthesiology, Kawasaki Municipal HospitalDepartment of Anesthesiology, Tokyo Dental College Ichikawa General HospitalDepartment of Diabetes, Endocrinology and Metabolism, Kyorin University School of MedicineDepartment of Anesthesia, Saitama Children?ˉs Medical CenterDepartment of Anesthesiology, Kyorin University School of MedicineDepartment of Anesthesiology and Critical Care Medicine, Graduate School of Medical Sciences, Kyushu UniversityDepartment of Anesthesiology, Kyorin University School of MedicineDepartment of Anesthesiology, Kitasato University School of MedicineDepartment of Anesthesiology, International University of Health and Welfare, School of MedicineDepartment of Anesthesiology, Kyorin University School of Medicine
医学研究方法内科学
sodium-glucose cotransporter 2 inhibitorsketoacidosisdiabetic ketoacidosissystematic reviewcase reports
Hoshijima Hiroshi,Motoyasu Akira,Kondo Kazuya,Yoshikawa Takahiro,Hyuga Shunsuke,Nagai Ai,Ono Motoaki,Ideno Satoshi,Ouchi Takashi,Yasuda Kazuki,Kuratani Norifumi,Seki Hiroyuki,Higashi Midoriko,Noguchi Hikari,Shishii Miho,Shiga Toshiya,Watanabe Hidenobu.Sodium-glucose cotransporter 2-associated perioperative ketoacidosis: a protocol for SAPKA systematic review[EB/OL].(2025-03-28)[2025-04-30].https://www.medrxiv.org/content/10.1101/2022.05.22.22275348.点此复制
评论