-半乳糖通过抑制mTOR信号导致实验小鼠认知功能障碍

Objective: This study intends to investigate the effects D-galactose on learning and memory in mice, and to explore its possible mechanism. Methods: 3-month-old healthy male ICR mice were randomly divided into normal control and D-galactose groups. Mice in D-galactose group were received daily subcutaneous injection of D-galactose at a dose of 1000 mg/kg and the normal group were received the same volume saline. After 10 weeks of injection, effect of D-galactose on the function of learning and memory was investigated by Morris water maze. The effect of D-galactose on mTOR protein in the hippocampus of mice was explored by Western Blotting method. Results:D-galactose can significantly prolong the incubation period in water maze and reduce P-mTOR protein content in mice hippocampus compared with normal group. Conclusion:D-galactose can damage the function of learning and memory in mice, it may be associated with inhibiting mTOR protein expression in hippocampus.