Subthreshold repetitive transcranial magnetic stimulation drives structural synaptic plasticity in the young and aged motor cortex
Subthreshold repetitive transcranial magnetic stimulation drives structural synaptic plasticity in the young and aged motor cortex
Abstract BackgroundRepetitive transcranial magnetic stimulation (rTMS) is a non-invasive tool commonly used to drive neural plasticity in the young adult and aged brain. Recent data from mouse models have shown that even at subthreshold intensities (0.12 Tesla), rTMS can drive neuronal and glial plasticity in the motor cortex. However, the physiological mechanisms underlying subthreshold rTMS induced plasticity and whether these are altered with normal ageing are unclear. ObjectiveTo assess the effect of subthreshold rTMS, using the intermittent theta burst stimulation (iTBS) protocol on structural synaptic plasticity in the mouse motor cortex of young and aged mice. MethodsLongitudinal in vivo 2-photon microscopy was used to measure changes to the structural plasticity of pyramidal neuron dendritic spines in the motor cortex following a single train of subthreshold rTMS (in young adult and aged animals) or the same rTMS train administered on 4 consecutive days (in young adult animals only). Data were analysed with Bayesian hierarchical generalized linear regression models and interpreted with the aid of Bayes Factors (BF). ResultsWe found strong evidence (BF>10) that subthreshold rTMS altered the rate of dendritic spine losses and gains, dependent on the number of stimulation sessions and that a single session of subthreshold rTMS was effective in driving structural synaptic plasticity in both young adult and aged mice. ConclusionThese findings provide further evidence that rTMS drives synaptic plasticity in the brain and uncovers structural synaptic plasticity as a key mechanism of subthreshold rTMS induced plasticity.
Garry Michael I、Bindoff Aidan D、Bolland Samuel、Collins Jessica、Langley Ross C、Summers Jeffery J、Tang Alexander D、Bennett William、Hinder Mark R、Canty Alison J、Rodger Jennifer
School of Psychological Sciences, College of Health and Medicine, University of TasmaniaWicking Dementia Research and Education Centre, College of Health and Medicine, University of TasmaniaExperimental and Regenerative Neurosciences, School of Biological Sciences, University of Western Australia||Perron Institute for Neurological and Translational SciencesWicking Dementia Research and Education Centre, College of Health and Medicine, University of TasmaniaWicking Dementia Research and Education Centre, College of Health and Medicine, University of TasmaniaSchool of Psychological Sciences, College of Health and Medicine, University of Tasmania||Research Institute for Sport and Exercise Sciences, Liverpool John Moores UniversityExperimental and Regenerative Neurosciences, School of Biological Sciences, University of Western Australia||Perron Institute for Neurological and Translational SciencesWicking Dementia Research and Education Centre, College of Health and Medicine, University of TasmaniaSchool of Psychological Sciences, College of Health and Medicine, University of TasmaniaWicking Dementia Research and Education Centre, College of Health and Medicine, University of TasmaniaExperimental and Regenerative Neurosciences, School of Biological Sciences, University of Western Australia||Perron Institute for Neurological and Translational Sciences
基础医学神经病学、精神病学生物科学研究方法、生物科学研究技术
Repetitive transcranial magnetic stimulationIntermittent theta burst stimulationStructural synaptic plasticityMotor cortexAgeing
Garry Michael I,Bindoff Aidan D,Bolland Samuel,Collins Jessica,Langley Ross C,Summers Jeffery J,Tang Alexander D,Bennett William,Hinder Mark R,Canty Alison J,Rodger Jennifer.Subthreshold repetitive transcranial magnetic stimulation drives structural synaptic plasticity in the young and aged motor cortex[EB/OL].(2025-03-28)[2025-04-27].https://www.biorxiv.org/content/10.1101/2021.03.10.434706.点此复制
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