苦马豆素抗肿瘤作用的研究进展

he indolizidine alkaloid swainsonine was initially isolated from Swainsona canescens, which was about thirty years up to now. Swainsonine, an highly specific alpha-mannosidase competitive inhibitor, can inhibit the expression of tumor cell glycoprotein andrestrain the tumor cells from growth and transfer. In addition, it can stimulate body immunologic system and enhance body immunity function, immunocyte generation and the activity of killing tumor cells. Because of its satisfactory antineplastic-activity and immunity-enhancement, swainsonine as the potential medicine of antineoplastic agents screening, is paid great attention to. Though, the study of swainsonine clinical treatment effect has been the phase Ⅲ abroad, it is inchoate in home at present. This article mainly revises the progress in research of swainsonine antineplastic-activity in both the direct and the indirect activity, and introduces the effects of swainsonine as a therapeutic drug.