利福平作为神经氨酸酶抑制剂的研究

Objective: Influenza causes significant human illness and death. Neuraminidase inhibitors which target at viral release are the most frequently used clinical anti-flu drugs. Here, through screening of a FDA-approved drug library, drugs were assessed to search for new neuraminidase inhibitors. Methods: Multiple influenza neuraminidase enzymatic models were constructed and used to screen the drug library. Results: Through screening of the drug library, Rifampin was found to have inhibitory effect of influenza viral neuraminidase. Conclusion: Rifampin could effectively inhibit the activity of multiple influenza viral neuraminidase and could accumulate information for the study of new anti-flu drugs.