EG-1在子宫内膜组织中的表达及与临床病理相关性的研究

Objective: To assess the expression of AEG-1 in different endometrial specimens and to investigate its relationship with clinicopathological features. Methods: Immunohistochemistry analysis was used to determine the expression levels of AEG-1 protein in 20 normal endometrium, 30 atypical endometrial hyperplasia and 126 endometrial cancers. The correlation between AEG-1 expression and various clinicopathologic characteristics of endometrial cancer patients was analyzed.Results: The frequent and strong expression of AEG-1 was gradually elevated in normal endometrial tissue, atypical hyperplasia and endometrial cancers, respectively. The Ki67 (a proliferation marker) was frequently expressed in the high AEG-1-expressed area, whereas areas with low AEG-1 levels showed weak Ki67 expression. AEG-1 over-expression was positively correlated with FIGO stage, depth of myometrial invasion, lymph node metastasis,. Conclusion: AEG-1 over-expression may be associated with carcinogenesis and tumor progression in endometrial cancer. Moreover, it may be a target for improving the treatment efficiency of endometrial cancer patients.