聚（N-乙烯基吡咯烷酮-co-甲基丙烯酸-β羟乙酯）/CMC半互穿网络水凝胶的制备以及对药物的控制释放
Study on Poly(HEMA/NVP/CMC) half interpenetrating Hydrogel as Drug Delivery Carriers
用N,N-亚甲基双丙烯酰胺（Bis）为交联剂，过硫酸铵（APS）为引发剂，羧甲基纤维素（CMC）为助剂，合成了聚（N-乙烯基吡咯烷酮-co-甲基丙烯酸-β羟乙酯）/CMC半互穿网络水凝胶，并在模拟人体环境的条件下，以非水溶性药物萘普生为模拟药物，考察了水凝胶在不同温度及酸度响应下的药物释放。，非水溶性药物萘普生在聚（N-乙烯基吡咯烷酮-co-甲基丙烯酸-β羟乙酯）/CMC半互穿网络水凝胶载体体系pH=2.00时，药物释放率受温度的影响较少，而在pH=7.40时，释放率受温度的影响较大。该凝胶作为萘普生口服释放载体具有较佳的释放性能。
N, N - and methyl double acrylamide (Bis) as crosslinking agent, ammonium persulfate (APS) as the initiator, carboxymethyl cellulose (CMC) for additives, the synthesis (N - vinyl pyrrole - co - methyl methacrylate hydroxyl ethyl ester) - beta/CMC half interpenetratinnetworks, and in the simulation hydrogel human environment conditions, non-aqueous drugs for simulating the drug naproxen and gel under different temperatures and acidity of the drug release under the response. Results showed that the water-soluble drugs naproxen in poly (N - vinyl pyrrole - co - methyl methacrylate hydroxyl ethyl ester) - beta/CMC half interpenetrating networks hydrogel carrier system pH = 2.00, drug release rate under the influence of the temperature of less, and in the pH = 7.40, release rate by the influence of the temperature. This gel as naproxen oral release carrier has better performance.
周逆舟
药学制药化学工业高分子化合物工业
N-乙烯基吡咯烷酮甲基丙烯酸-β羟乙酯MC半互穿网络水凝胶萘普生药物释放
N - vinyl pyrroleMethyl methacrylate hydroxyl ethyl esterthe beta - The CMCHalf interpenetrating networks of control gelNaproxenhe drug release
周逆舟.聚（N-乙烯基吡咯烷酮-co-甲基丙烯酸-β羟乙酯）/CMC半互穿网络水凝胶的制备以及对药物的控制释放[EB/OL].(2011-03-17)[2025-08-21].http://www.paper.edu.cn/releasepaper/content/201103-766.点此复制
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