ickkopf-1与抗酒石酸酸性磷酸酶5b(TRAP5b)在类风湿关节炎骨破坏中的意义

Objectives To investigate the roles of circulating Dickkopf-1(DKK-1) and tartrate-resistant acid phosphatase 5b (TRAP5b) in RA patients with bone destruction and osteoporosis. Methods Serum samples were obtained from 230 RA, 50 osteoarthritis (OA) and 150 health controls. Synovial fluid (SF) was collected from 45 RA and 15 OA patients, and 15 paired sera were collected from these RA patients. The level of DKK-1 and TRAP5b were measured by ELISA. Results Serum DKK-1 of RA patients were significantly higher than OA and health controls (P<0.001); SF DKK-1 was significantly higher in RA than in OA (P=0.007), which was correlated with paired sera in RA(r=0.860,P<0.0001); There was obvious discrepancy of TRAP5b in RA patients with and without osteoporosis(P<0.001). However, such discrepancy wasn't displayed in serum DKK-1 level (P>0.05); Serum DKK-1 and serum TRAP5b activity was positive correlated with disease duration and Sharp score(P<0.05). Conclusion Circulating DKK-1 and TRAP5b activity were closely related to systemic bone metabolism imbalance and local bone destruction in patients with RA.