程序性坏死的分子机制研究进展

For a long time, apoptosis is widely believed the only way of programmed cell death in the growth and development of organism, disease, and maintain homeostasis. Meanwhile, necroptosis is considered to be a non-regulated process of cell death. Recently, many reports have revealed that necrosis may be a cell death that can be regulated by specific molecular pathway, named necroptosis. The initiation of necroptosis needs the activation of TNF-alpha, and the kinase activity of RIP1 and RIP3 play a critical role in it. In this review, the crucial role of RIP3 in necroptosis, the molecular structure characterization of it, and the interaction with other molecules of necroptosis associated signaling pathways were summarized.