急性六价铬中毒对小鼠成体神经发生影响的研究

［Objective］To investigate the influence of acute chromium（Ⅵ）poisoning on the proliferation and survival of adult neural stem cells in the SGZ of the dentate gyrus in mice. [Methods］Healthy Adult Kunming mice were divided into two groups: control group and experimental poisoning group.Exposure to chromium（Ⅵ）by intraperitoneal injection, Immunocytochemistry was used to investigate quantificationally the proliferation and survival of adult neural stem cells in the SGZ of the dentate gyrus in mice.［Results］The number of BrdU-positive cells per 1000μm in the dentate gyrus of experimental poisoning mice was significantly increased by 17% compared with the control group (P<0.05),however the newly generated cells of the survival significantly decreased by 25% in experimental poisoning group compared with the control group (P<0.05),indicating that the differentiation and survival of adult neural stem cells were significant influenced by the acute chromium（Ⅵ）poisoning. ［Conclusion］These results suggest that cute chromium（Ⅵ）poisoning enhances the proliferation of adult neural stem cells and induces the deficit in the survival of newly generated cells in the SGZ of the dentate gyrus in mice, the alterations in level of cell is foundation that may help the organism deal with chromium（Ⅵ）poisoning and urge itself to recover from injury.