构建用于组织修复的多价核酸药物

hronic trauma has a high incidence, and the actual cure rate is much lower than the public 90%. Whether it is insufficient healing or excessive healing, it will bring huge economic burden and physiological pain to patients, so it is very important to promote the process of tissue repair for the treatment of related diseases. Nucleic acid molecules have high biocompatibility and controllable molecular size. DNA nanotechnology can be used to design DNA ligands targeting FGFR1. In addition, the multivalent effect plays an important role in the formation of membraneless organelles and cell adhesion. Based on the polyvalent effect, researchers have developed drug molecules for different scenarios. In this study, on the basis of oligonucleotides targeting FGFR1, DNA multivalent ligands were constructed to regulate cell signal transduction, promote cell proliferation and migration and promote the process of tissue repair.