视神经脊髓炎患者脑脊液里可溶性C5b-9变化
Increased soluble C5b-9 in CSF of neuromyelitis optica
视神经脊髓炎(NMO)和多发性硬化(MS)是中枢神经系统疾病的两大自身免疫性炎性脱髓鞘性疾病。补体被认为是在这些疾病里发挥了重要的作用。然而，在NMO病人中终端补体复合物(TCC, C5b-9)的改变尚不清楚。用酶联免疫吸法(ELISA)检测NMO (n=26)、MS (n=25)及其他神经功能疾病对照(OND, n=19)患者脑脊液(CSF)C3a, C5a, 可溶性C5b-9(sC5b-9)变化。我们发现NMO患者CSF C5a水平比OND病升高(P=0.006)。NMO患者脑脊液里sC5b-9表达比MS患者(P = 0.029)和OND患者水平高(p=0.0001)，并且MS病人脑脊液的sC5b-9水平也比OND病人的高(p=0.030)。NMO患者复发期sC5b-9与EDSSS评分呈正相关性(p=0.006)。NMO病人脑脊液里sC5b-9水平增加且反映了补体的激活，反应了疾病的严重性。
Neuromyelitis optica (NMO) and multiple sclerosis (MS) are two of the autoimmune inflammatory demyelinating diseases in the central nervous system. Complement is thought to have an important role in pathogenesis of these diseases, especially in NMO. However, the change of terminal complement complex (TCC, C5b-9) in patients with NMO is still unclear. Cerebrospinal fluid (CSF) C3a, C5a, sC5b-9 were measured by enzyme-linked immunosorbent assay in patients with NMO (n = 26), MS (n = 25) and other neurological disease (OND, n = 19). CSF levels of C5a in patients with NMO were higher than patients with OND (P = 0.006). Increased CSF sC5b-9 were found in the patients with NMO compared with patients with MS (P = 0.029) and OND (P = 0.0001). CSF sC5b-9 in patients with MS were also higher than patients with OND (P = 0.030). Patients with NMO revealed a trend to an increased disease disability with increased CSF sC5b-9 during relapse but not in MS (NMO: P = 0.006, MS: P = 0.097). CSF levels of sC5b-9 are increased in patients with NMO and reflect the activation of complement in NMO.
汪鸿浩、邱伟、胡学强、陆正齐、汪凯
神经病学、精神病学基础医学临床医学
神经病学视神经脊髓炎多发性硬化补体5b-9
neurologyneuromyelitis opticamultiple sclerosisCSFC5b-9
汪鸿浩,邱伟,胡学强,陆正齐,汪凯.视神经脊髓炎患者脑脊液里可溶性C5b-9变化[EB/OL].(2016-06-17)[2025-08-10].http://www.paper.edu.cn/releasepaper/content/201606-744.点此复制
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