Association between Cardiovascular Burden and Requirement of Intensive Care among Patients with Mild COVID-19
Association between Cardiovascular Burden and Requirement of Intensive Care among Patients with Mild COVID-19
Abstract BackgroundInformation regarding the impact of cardiovascular disease (CVD) on disease progression among patients with mild coronavirus disease 2019 (COVID-19) is limited. MethodsThis study evaluated the association of underlying CVD with disease progression in patients with mild COVID-19. The primary outcome was the need to be transferred to intensive care due to disease progression. The patients were divided with and without CVD as well as stable and intensive care groups. ResultsOf 332 patients with mild COVID-19, median age was 51 years (IQR, 40-59 years), and 200 (61.2%) were female. Of 48 (14.5%) patients with CVD, 23 (47.9%) progressed to severe disease status and required intensive care. Compared with patients without CVD, patients with CVD were older, and more likely to have fatigue, chest tightness, and myalgia. The rate of requiring intensive care was significantly higher among patients with CVD than in patients without CVD (47.92% vs. 12.4%; P<0.001). In subgroup analysis, rate of requiring intensive care was also higher among patients with either hypertension or coronary heart disease than in patients without hypertension or coronary heart disease. The multivariable regression model showed CVD served as an independent risk factor for intensive care (Odd ratio [OR], 2.652 [95% CI, 1.019-6.899]) after adjustment for various cofounders. ConclusionsPatients with mild COVID-19 complicating CVD in are susceptible to develop severe disease status and requirement for intensive care. Key PointsQuestionWhat is the impact of coexisting cardiovascular diseases (CVD) on disease progression in patients with mild COVID-19?FindingsAlthough most patients with mild COVID-19 were discharged alive from hospital, approximately 47.9% patients with coexisting CVD developed severe disease status and required intensive care. CVD is an independent risk factor of intensive care among patients with mild COVID-19.MeaningCoexisting CVD is associated with unfavorable outcomes among patients with mild COVID-19. Special monitoring is required for these patients to improve their outcome.
He Yuhu、Xu Junmei、Tai Shi、Tang Jianjun、Wang Yang、Wen Chuan、Jiang Zhongbiao、Zhu Li、Liu Qiming、Fang Zhenfei、Sun Jiaxing、Tang Liang、Li Xuping、Tan Chongqin、Yang Hui、Chen Mingxian、Zhu Zhaowei、Jiang Li、Jiang Chuanhao、Chai Xiangping、Zhang Huilin、Hu Xinqun、Xiao Yichao、Tu Tao、Yu Bilian、Zhou Shenghua、Zhu Weihong、Xiao Kui
Department of Cardiology, the Second Xiangya Hospital of Central South UniversityDepartment of Anesthesiology, the Second Xiangya Hospital of Central South UniversityDepartment of Cardiology, the Second Xiangya Hospital of Central South University||National Emergency Medical TeamDepartment of Cardiology, the Second Xiangya Hospital of Central South University||National Emergency Medical TeamNational Emergency Medical TeamNational Emergency Medical TeamNational Emergency Medical TeamNational Emergency Medical TeamDepartment of Cardiology, the Second Xiangya Hospital of Central South UniversityDepartment of Cardiology, the Second Xiangya Hospital of Central South UniversityDepartment of Cardiology, the Second Xiangya Hospital of Central South UniversityDepartment of Cardiology, the Second Xiangya Hospital of Central South University||National Emergency Medical TeamDepartment of Cardiology, the Second Xiangya Hospital of Central South UniversityNational Emergency Medical TeamDepartment of Cardiology, the Second Xiangya Hospital of Central South UniversityDepartment of Cardiology, the Second Xiangya Hospital of Central South UniversityDepartment of Cardiology, the Second Xiangya Hospital of Central South UniversityNational Emergency Medical TeamNational Emergency Medical TeamDepartment of Emergency medicine, the Second Xiangya Hospital of Central South University||National Emergency Medical TeamNational Emergency Medical TeamDepartment of Cardiology, the Second Xiangya Hospital of Central South UniversityDepartment of Cardiology, the Second Xiangya Hospital of Central South UniversityDepartment of Cardiology, the Second Xiangya Hospital of Central South UniversityDepartment of Cardiology, the Second Xiangya Hospital of Central South University||National Emergency Medical TeamDepartment of Cardiology, the Second Xiangya Hospital of Central South UniversityNational Emergency Medical TeamNational Emergency Medical Team
临床医学内科学
Coronavirus disease 2019COVID-19SARS-CoV-2Cardiovascular diseases
He Yuhu,Xu Junmei,Tai Shi,Tang Jianjun,Wang Yang,Wen Chuan,Jiang Zhongbiao,Zhu Li,Liu Qiming,Fang Zhenfei,Sun Jiaxing,Tang Liang,Li Xuping,Tan Chongqin,Yang Hui,Chen Mingxian,Zhu Zhaowei,Jiang Li,Jiang Chuanhao,Chai Xiangping,Zhang Huilin,Hu Xinqun,Xiao Yichao,Tu Tao,Yu Bilian,Zhou Shenghua,Zhu Weihong,Xiao Kui.Association between Cardiovascular Burden and Requirement of Intensive Care among Patients with Mild COVID-19[EB/OL].(2025-03-28)[2025-04-26].https://www.medrxiv.org/content/10.1101/2020.05.25.20111757.点此复制
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