高稳定性的L-DNA荧光传感器用于汞离子和银离子的检测

his work reports a sensitive biosensing platorm for the detection of Hg2+ or Ag+ by combining the "T-Hg2+-T" pairs, "C-Ag+-C" pairs with the principle of chiral recognition mechanism. The non-nature L-DNA is the mirror-image enantiomer of nature D-DNA, which has identical physical and chemical properties. Also, L-DNA can specifically recognize the achiral targets with similar sensitivity of traditional D-DNA. Hence, L-DNA probes were constructed to detect achiral molecules Hg2+ and Ag+. This design achieves high selectivity and good sensitivity with extra merits of excellent biostability, which can resist nuclease digestion in complex practical samples. This design provides new insight to construct biostable biosensors.