钯催化末端炔烃区域选择性成环合成2(5H)-呋喃酮类化合物反应研究
Palladium-catalyzed synthesis of furanones through regioselective carbonylative annulation of terminal alkynes
发展了钯催化氧化末端炔烃的羰基化反应高效合成2(5H)-呋喃酮类化合物，该反应成功实现了末端炔烃区域选择性羰化成环反应，并且具有广泛的底物适应性和较好的产率，丰富了合成2(5H)-呋喃酮的路线。利用TBHP作为氧化剂，可以避免氧化羰基化中氧气的爆炸极限，使反应安全、绿色、高效地合成了多官能化的呋喃酮类化合物。
We have developed a mid and efficient Pd-catalyzed carbonylative annulation of terminal alkynes to construct the furanones. Terminal alkynes is the powerful and versatile building block to construct the corresponding chromones in moderate to excellent yields. The use of TBHP applied as oxidant not only solved thethe explosion limit of CO, but also represented an efficient and clean route to synthesis of the furanones.
卓克垒、刘娜、刘建明
精细化学工业有机化学工业制药化学工业
物理化学末端炔烃氧化2(5H)-呋喃酮
Physical Chemistryterminal alkynecarbonylation2 (5H)- furanone
卓克垒,刘娜,刘建明.钯催化末端炔烃区域选择性成环合成2(5H)-呋喃酮类化合物反应研究[EB/OL].(2015-11-20)[2025-08-02].http://www.paper.edu.cn/releasepaper/content/201511-292.点此复制
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