硫化氢荧光探针的构建及其应用的研究进展综述

Hydrogen sulfide (H2S) is the third gaseous signal molecule of life system after the discovery of nitric oxide and carbon monoxide. It is produced by various enzymatic reactions. It has a dual effect similar to that caused by concentration change, and has a wide range of action, and has important physiological functions in cardiovascular, nervous and energy metabolism systems. Fluorescence detection technology has high sensitivity and selectivity, and can be more accurate in cell and molecular imaging. Therefore, selective detection of hydrogen sulfide has a very important role and value. In this paper, the mechanism of H2S fluorescence probes, thiolysis of aromatic nitro groups, synthesis of aromatic nitro groups, h2S-mediated reduction and copper replacement are reviewed.