天然产物Murrayaquinone A、Koeniginequinone B及其衍生物的合成研究

arbazolequinone alkaloids, a common and important class of nature products, exhibit promising bioactivity in antitumor, antimalaria, antiviral, antibacterial, etc. Murrayaquinone A and koeniginequinone B as the simplest carbazolequinone compounds, have attracted extensive concern for their significant antitumor activity. In this research, we designed a new synthetic route for a series of substituted methyl benzene quinone amine. Subsequently, murrayaquinone A、koeniginequinone B and a series of their analogues have been synthesized efficientlyapplying aryne chemistry, which is based on our new methodology of synthsizing carbazolequinones. This work paves the base for further biological activity test and structure-activity relationship study.