NF-α抑制剂治疗类风湿关节炎相关基因的生物信息学分析
Bioinformatic analysis of genes related to Rheumatoid Arthritis treated by TNF-α inhibitor
目的 用生物信息学方法探讨TNF-α抑制剂治疗类风湿关节炎的相关基因，为探讨TNF-α抑制剂治疗类风湿关节炎的机制提供新思路。 方法 从基因芯片公共数据库Gene Expression Omnibus (GEO)中下载TNF-α抑制剂治疗类风湿关节炎的相关基因芯片数据，利用String、KEGG、Panther等在线分析软件对差异表达基因进行生物信息学分析。 结果 在60个差异表达基因所编码的蛋白中，有29个蛋白与其他蛋白存在相互作用关系，作用过程涉及多种生物学通路，与多个生物学过程和分子功能相关。 结论 TNF-α抑制剂治疗类风湿关节炎涉及多基因相互作用，与NF-κB信号通路、MAPK信号通路关系密切。
Objective To investigate the genes associated with Rheumatoid Arthritis treated by TNF-α inhibitor with bioinformatics methods to provide new ideas for the research of mechanism of Rheumatoid Arthritis treated by TNF-α inhibitor. Methods The microarray data of Rheumatoid Arthritis treated by TNF-α inhibitor were downloaded from the Gene Expression Omnibus (GEO) database and analyzed by bioinformatics methods using String, KEGG and Panther databases. Results Of all the 60 differentially expressed genes, 29 were found to encode proteins with interactions; they involved to multiple biological pathways, biological processes and molecular functions. Conclusion The pathogenesis of Rheumatoid Arthritis treated by TNF-α inhibitor involves multiple genes, which closely related to NF-κB and MAPK signaling pathways.
吕蔚然、马利、周淑清、李长征、周烨
医药卫生理论医学研究方法基础医学
类风湿关节炎NF-α抑制剂基因芯片生物信息学
Rheumatoid ArthritisTNF-α inhibitorDNA microarrayBioinformatics
吕蔚然,马利,周淑清,李长征,周烨.NF-α抑制剂治疗类风湿关节炎相关基因的生物信息学分析[EB/OL].(2013-03-19)[2025-08-02].http://www.paper.edu.cn/releasepaper/content/201303-666.点此复制
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