发育及DNA损伤反应调节基因1在肿瘤发生发展中的作用机制研究
Function of Regulated in development and DNA damage response 1 in cancer and its mechanism
发育及DNA损伤反应调节基因1（Regulated in development and DNA damage response 1，REDD1）是近年来发现缺氧诱导因子-1（ Hypoxia-induced factor-1，HIF-1）下游重要的靶基因，在多种肿瘤细胞中广泛表达,参与多种肿瘤信号转导通路。本文就REDD1参与影响肿瘤生长、凋亡、自噬和耐药形成等方面的研究进展作一综述。
Regulated in development and DNA damage response 1(REDD1)was a significant target gene of Hypoxia-induced factor-1(HIF-1). It is widely expressed in multiple kinds of tumor cells and involved in various signal pathways. This article reviews the progress of REDD1 in influencing cancer growth、apoptosis、autophagy and drug resistance.
胡明玥、申霞、周玲娜、常立功、黄培林
肿瘤学基础医学分子生物学
肿瘤，发育及DNA损伤反应调节基因1，凋亡，自噬
tumor REDD1 apoptosis autophagy
胡明玥,申霞,周玲娜,常立功,黄培林.发育及DNA损伤反应调节基因1在肿瘤发生发展中的作用机制研究[EB/OL].(2016-05-24)[2025-08-16].http://www.paper.edu.cn/releasepaper/content/201605-1111.点此复制
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