骨质疏松中衰老相关分泌表型调控机制的研究进展

Senescence-associated secretory phenotype SASP is an important feature of cellular senescence and plays an important role in regulating the disease microenvironment. At presentthe role of SASP in intervening bone metabolism and inducing bone loss is very limited. Thereforethis paper discusses the regulatory mechanism of SASP in osteoporosis models and summarizes its regulatory characteristics1. SASP is fully expressed in senescent bone cells and transmits aging effects to mesenchymal stem cells in an autocrine/paracrine mannerthereby interfering with osteogenic differentiation. 2. SASP activates immune cells and promotes their agingthus inducing the formation of inflammatory tissue microenvironment and aggravating bone loss. 3. Mitochondrial homeostasispathologic hyperglycemiaand obesity-induced fat accumulation all promote SASP expressionthus disrupting microenvironmental homeostasis and transmitting aging effects to bone tissue. To sum upunderstanding the role of SASP in osteoporosis lays a solid foundation for us to develop anti-SASP therapy for osteoporosis in the future.