原位生成法制备生物相容性磁性粒子

In this paper, a series of random copolymers with different ratios of 2-methacryloyloxy ethylphosphorylcholine to methacrylic acid were synthesized firstly via RAFT living polymerization. Then Fe3O4 magnetical particles(MNPs) coated with a well defined copolymer poly(2-methacryloyloxyethyl phosphorylcholine-co-methacrylic acid) P(MPC-co-MAA ) were synthesized by an in situ producing method. The results indicated that the water-solubility,stability and biocompatibity of MNPs had been improved remarkably.The influence of the ratio between the two monomers as well as the ratio between carboxyl and ferric ions on the properties of MNPs were also studied. The result demonstrated that PMPCMAA@MNPs with n(PMPCMAA73):n(Fe3O4)=1:1 shows the best water-solubility, stability and biocompatibity in all the samples we studied.