超重肥胖儿童的脂代谢异常与INSIG2基因变异有关
ssociation of Abnormal Lipid Metabolism with INSIG2 Gene Variant in Ovewight and Obese Children
目的：研究儿童超重肥胖和脂代谢与胰岛素诱导基因2（INSIG2）变异的相关性。方法：选择北京市2030名7～18岁的儿童进行身体测量、血脂和INSIG2基因rs13428113多态性检测。结果：研究对象rs13428113多态性的等位基因突变率(T>C)为49.3%。比较体重正常、超重和肥胖组基因型及等位基因频率，发现三组差异无统计学意义（p>0.05）。在超重组中CC基因型携带者的体质指数、腰臀比、肱三头肌和髂前上棘皮褶厚度高于TT/TC基因型携带者；在肥胖组中CC携带者总胆固醇水平高于TT/TC携带者（p0.05）。结论：INSIG2基因rs13428113多态性与超重、肥胖儿童的脂代谢异常有关，可能加重肥胖、血脂异常程度。
Objective: To study the relationship between insulin induced gene 2 (INSIG2) variant and obesity or lipid metabolism in Chinese children and adolescents. Methods: Altogether 2030 school students at the age from 7 to 18 years were selected in Beijing. Physical indicators, serum lipids and the rs13428113 polymorphism in INSIG2 gene were examined for all the subjects. Results: The mutation rate of the rs13428113 polymorphism (T>C) was 49.3%. The differences of genotype and allele frequencies were not statistically significant among the normal-weight, overweight and obesity groups (p>0.05). Among the overweight students, those with CC genotype had higher body mass index, waist-hip ratio, branchial triceps skinfold, and anterior superior iliac spine skinfold than TT/TC carriers. Among the obese group, those with CC genotype had higher total cholesterol than TT/TC carriers (P<0.05). Conclusion: The rs13428113 polymorphism in INSIG2 gene was associated with abnormal lipid metabolism in overweight and obese children, increasing the degree of obesity and abnormal serum lipids.
张衡、张伋、马军、王海俊、王燕
基础医学儿科学遗传学
儿童肥胖INSIG2基因
hildrenObesityINSIG2 gene
张衡,张伋,马军,王海俊,王燕.超重肥胖儿童的脂代谢异常与INSIG2基因变异有关[EB/OL].(2009-09-18)[2025-08-10].http://www.paper.edu.cn/releasepaper/content/200909-528.点此复制
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