OX40/OX40L共刺激途径在移植免疫中的作用及研究进展

lymphocytes play an important role,in acute allograft rejectionn and its activation requires two stimuli, OX40 / OX40L pathway is an important co-stimulatory signals.OX40 and the ligand of OX40(OX40L) were important menmbers of tumor necrosis factorfamily. OX40 was expressed predominately on activated CD4+ T cells and CD8+ T cells. While OX40L was expressed predominately on dectritic cell and B-lymphocytes. The interactions of OX40 and OX40L delivered the co-stimulatory signal which played a key role in sustaining primary CD4+T-lymphocyte responses, increased the number of cells entering the memory cell pool and was involved in the reactivation of Th2 memory cells. The Role of OX40/OX40L in transplantation immunity has also been further study.